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Infectious mononucleosis

MedGen UID:
7069
•Concept ID:
C0021345
•
Disease or Syndrome
Synonyms: Fever, Glandular; Glandular Fever; Infectious Mononucleosis; Mononucleosis, Infectious
SNOMED CT: Pfeiffer's disease (271558008); Gammaherpesviral mononucleosis (186668002); Infectious mononucleosis (271558008); Infective mononucleosis (271558008); Glandular fever (271558008); GF - Glandular fever (271558008); Monocytic angina (271558008); IM - Infective mononucleosis (271558008); IM - Infectious mononucleosis (271558008)
 
Monarch Initiative: MONDO:0005810

Definition

A clinical syndrome of fever, sore throat, fatigue, and lymphadenopathy caused by infection with the Epstein-Barr virus. Subsequent physical findings may include hepatomegaly, palatal petechiae, jaundice, uvular edema, and splenomegaly. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious mononucleosis

Professional guidelines

PubMed

Treatment of Epstein-Barr Virus infection in immunocompromised patients.
Pociupany M, Snoeck R, Dierickx D, Andrei G
Biochem Pharmacol 2024 Jul;225:116270. Epub 2024 May 10 doi: 10.1016/j.bcp.2024.116270. PMID: 38734316
Splenomegaly: Diagnosis and Management in Adults.
Aldulaimi S, Mendez AM
Am Fam Physician 2021 Sep 1;104(3):271-276. PMID: 34523897
Infectious Mononucleosis Management in Athletes.
Ceraulo AS, Bytomski JR
Clin Sports Med 2019 Oct;38(4):555-561. Epub 2019 Jul 29 doi: 10.1016/j.csm.2019.06.002. PMID: 31472766

Recent clinical studies

Etiology

Analysis of the epidemiology and clinical characteristics of Epstein-Barr virus infection.
Ding B, Zhang Y, Wu Y, Li Y
J Med Virol 2024 Oct;96(10):e29960. doi: 10.1002/jmv.29960. PMID: 39380297

Diagnosis

Analysis of the epidemiology and clinical characteristics of Epstein-Barr virus infection.
Ding B, Zhang Y, Wu Y, Li Y
J Med Virol 2024 Oct;96(10):e29960. doi: 10.1002/jmv.29960. PMID: 39380297

Therapy

Amoxicillin Rash in Infectious Mononucleosis.
Mergoum AM
N Engl J Med 2021 Sep 9;385(11):1033. doi: 10.1056/NEJMicm2104358. PMID: 34496177
Infections of the Oropharynx.
Klein MR
Emerg Med Clin North Am 2019 Feb;37(1):69-80. doi: 10.1016/j.emc.2018.09.002. PMID: 30454781
Vaccine Development for Epstein-Barr Virus.
Cohen JI
Adv Exp Med Biol 2018;1045:477-493. doi: 10.1007/978-981-10-7230-7_22. PMID: 29896681Free PMC Article
Infectious mononucleosis.
Luzuriaga K, Sullivan JL
N Engl J Med 2010 May 27;362(21):1993-2000. doi: 10.1056/NEJMcp1001116. PMID: 20505178
Epstein-Barr virus infectious mononucleosis.
Ebell MH
Am Fam Physician 2004 Oct 1;70(7):1279-87. PMID: 15508538

Prognosis

The Evolving Epidemiology of Nasopharyngeal Carcinoma.
Chang ET, Ye W, Zeng YX, Adami HO
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1035-1047. Epub 2021 Apr 13 doi: 10.1158/1055-9965.EPI-20-1702. PMID: 33849968
Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291
Epstein-Barr virus infectious mononucleosis.
Ebell MH
Am Fam Physician 2004 Oct 1;70(7):1279-87. PMID: 15508538
Infectious mononucleosis.
Peter J, Ray CG
Pediatr Rev 1998 Aug;19(8):276-9. doi: 10.1542/pir.19-8-276. PMID: 9707718

Clinical prediction guides

Infectious Mononucleosis: An Updated Review.
Leung AKC, Lam JM, Barankin B
Curr Pediatr Rev 2024;20(3):305-322. doi: 10.2174/1573396320666230801091558. PMID: 37526456
Causal association between inflammatory bowel disease and herpes virus infections: a two-sample bidirectional Mendelian randomization study.
Zou M, Zhang W, Shen L, Xu Y, Zhu Y
Front Immunol 2023;14:1203707. Epub 2023 Jul 3 doi: 10.3389/fimmu.2023.1203707. PMID: 37465669Free PMC Article
Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Primary Epstein-Barr virus infection.
Dunmire SK, Verghese PS, Balfour HH Jr
J Clin Virol 2018 May;102:84-92. Epub 2018 Mar 5 doi: 10.1016/j.jcv.2018.03.001. PMID: 29525635

Recent systematic reviews

The utility of liver function tests and abdominal ultrasound in infectious mononucleosis-A systematic review.
Tan ET, Wilkinson D, Edafe O
Clin Otolaryngol 2022 Nov;47(6):611-619. Epub 2022 Jul 29 doi: 10.1111/coa.13965. PMID: 35834363
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Splenic rupture in infectious mononucleosis: A systematic review of published case reports.
Bartlett A, Williams R, Hilton M
Injury 2016 Mar;47(3):531-8. Epub 2015 Oct 31 doi: 10.1016/j.injury.2015.10.071. PMID: 26563483
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

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